Article
Highly heterogeneous mutation rates in the hepatitis C virus genome.
Nature microbiology - 18 Apr 2016
Geller Ron, Estada Úrsula, Peris Joan B, Andreu Iván, Bou Juan-Vicente, Garijo Raquel, Cuevas José M, Sabariegos Rosario, Mas Antonio, Sanjuán Rafael
Abstract excerpt
Spontaneous mutations are the ultimate source of genetic variation and have a prominent role in evolution. RNA viruses such as hepatitis C virus (HCV) have extremely high mutation rates, but these rates have been inferred from a minute fraction of genome sites, limiting our view of how RNA viruses create diversity. Here, by applying high-fidelity ultradeep sequencing to a modified replicon system, we scored...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.