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Article

FKBP5 genotype-dependent DNA methylation and mRNA regulation after psychosocial stress in remitted depression and healthy controls.

The international journal of neuropsychopharmacology - 13 Dec 2014

Höhne Nina, Poidinger Maximilian, Merz Franziska, Pfister Hildegard, Brückl Tanja, Zimmermann Petra, Uhr Manfred, Holsboer Florian, Ising Marcus

Abstract excerpt

BACKGROUND: Polymorphisms in the FK506 binding protein 5 (FKBP5) gene have been shown to influence glucocorticoid receptor sensitivity, stress response regulation, and depression risk in traumatized subjects, with most consistent findings reported for the functional variant rs1360780. In the present study, we investigated whether the FKBP5 polymorphism rs1360780 and lifetime history of major depression are...

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Identifiers

PMID: 25522420
DOI: 10.1093/ijnp/pyu087
PMCID: PMC4360217

Genes

FKBP5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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FKBP5 genotype-dependent DNA methylation and mRNA regulation after psychosocial stress in remitted depression and healthy controls.PMID 25522420Read ↗

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The rs1360780 Variant of FKBP5: Genetic Variation, Epigenetic Regulation, and Behavioral PhenotypesSemantic proximity Read ↗

Polymorphisms in the FKBP5 gene region modulate recovery from psychosocial stress in healthy controls.Semantic proximity Read ↗

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