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Article

Polymorphisms in the FKBP5 gene region modulate recovery from psychosocial stress in healthy controls.

The European journal of neuroscience - 1 Jul 2008

Ising Marcus, Depping Anna-Mareike, Siebertz Anna, Lucae Susanne, Unschuld Paul G, Kloiber Stefan, Horstmann Sonja, Uhr Manfred, Müller-Myhsok Bertram, Holsboer Florian

Abstract excerpt

Mood and anxiety disorders are considered stress-related diseases characterized by an impaired function of mineralocorticoid and glucocorticoid receptors (MR and GR, respectively), the major regulatory elements of the hypothalamus-pituitary-adrenocortical (HPA) axis. A number of so-called chaperone proteins moderate the function of these receptors. Genetic variations in one of these chaperones, FKBP5, were...

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Source

Identifiers

PMID: 18702710
DOI: 10.1111/j.1460-9568.2008.06332.x

Genes

FKBP5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Polymorphisms in the FKBP5 gene region modulate recovery from psychosocial stress in healthy controls.PMID 18702710Read ↗

Genetic association of FKBP5 and CRHR1 with cortisol response to acute psychosocial stress in healthy adults.Semantic proximity Read ↗

The role of FKBP5, a co-chaperone of the glucocorticoid receptor in the pathogenesis and therapy of affective and anxiety disorders.Semantic proximity Read ↗

The rs1360780 Variant of FKBP5: Genetic Variation, Epigenetic Regulation, and Behavioral PhenotypesSemantic proximity Read ↗

Moderating role of FKBP5 genotype in the impact of childhood adversity on cortisol stress response during adulthood.Semantic proximity Read ↗

FKBP5 genotype-dependent DNA methylation and mRNA regulation after psychosocial stress in remitted depression and healthy controls.Semantic proximity Read ↗

Effect of the common functional FKBP5 variant (rs1360780) on the hypothalamic-pituitary-adrenal axis and peripheral blood gene expression.Semantic proximity Read ↗

DNA sequence variants of the FKBP5 gene are associated with unipolar depression.Semantic proximity Read ↗

Gene-Stress-Epigenetic Regulation of FKBP5: Clinical and Translational Implications.Semantic proximity Read ↗

Targeting glucocorticoid receptor signaling pathway for treatment of stress-related brain disordersSemantic proximity Read ↗

FKBP5 polymorphism is associated with major depression but not with bipolar disorder.Semantic proximity Read ↗

Interaction of FKBP5 gene variants and adverse life events in predicting depression onset: results from a 10-year prospective community study.Semantic proximity Read ↗

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