Article
Genetic association of FKBP5 and CRHR1 with cortisol response to acute psychosocial stress in healthy adults.
Psychopharmacology - 1 May 2013
Mahon Pamela Belmonte, Zandi Peter P, Potash James B, Nestadt Gerald, Wand Gary S
Abstract excerpt
RATIONALE: Chronic dysregulation of hypothalamus-pituitary-adrenal (HPA) axis activity is related to several neuropsychiatric disorders. Studies suggest that cortisol response to stress has a strong genetic etiology, and that FK506 binding protein 5 (FKBP5) and G-protein coupled type-I CRH receptor (CRHR1) are key proteins regulating response. Variations in the genes encoding these proteins, FKBP5 and CRHR1, have...
Topics
- Adolescent
- Adult
- Female
- Humans
- Hydrocortisone
- Hypothalamo-Hypophyseal System
- Male
- Pituitary-Adrenal System
- Polymorphism, Single Nucleotide
- Psychological Tests
- Receptors, Corticotropin-Releasing Hormone
- Saliva
- Sex Factors