Article
Epigenetic Changes of FKBP5 as a Link Connecting Genetic and Environmental Risk Factors with Structural and Functional Brain Changes in Major Depression.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 Apr 2018
Tozzi Leonardo, Farrell Chloe, Booij Linda, Doolin Kelly, Nemoda Zsofia, Szyf Moshe, Pomares Florence B, Chiarella Julian, O'Keane Veronica, Frodl Thomas
Abstract excerpt
The gene for the glucocorticoid receptor regulator FK506 binding protein 5 (FKBP5) plays a role for risk, response to treatment, and changes in brain areas in major depressive disorder (MDD). Chronic stress is associated with lower methylation of FKBP5. Our aim was to investigate whether methylation of FKBP5 reflected exposure to childhood adversity in MDD and controls and whether it was associated with structure...
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