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Article

No association between FKBP5 gene methylation and acute and long-term cortisol output.

Translational psychiatry - 2 Jun 2020

Alexander Nina, Kirschbaum Clemens, Stalder Tobias, Muehlhan Markus, Vogel Susanne

Abstract excerpt

Prior studies identified DNA methylation (DNAM) changes in a regulatory region within the FK506 binding protein 5 (FKBP5) gene as a crucial mediator of long-term negative health outcomes following early adversity. A critical mechanism underlying this link, in turn, has been suggested to be epigenetically induced dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis. The purpose of this study was thus to...

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Identifiers

PMID: 32488091
DOI: 10.1038/s41398-020-0846-2
PMCID: PMC7266811

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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