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The FKBP5 genotype and childhood trauma effects on FKBP5 DNA methylation in patients with psychosis, their unaffected siblings, and healthy controls.

Psychoneuroendocrinology - 1 Jun 2021

Mihaljevic Marina, Franic Dusanka, Soldatovic Ivan, Lukic Iva, Petrovic Sanja Andric, Mirjanic Tijana, Stankovic Biljana, Zukic Branka, Zeljic Katarina, Gasic Vladimir, Novakovic Ivana, Pavlovic Sonja, Adzic Miroslav, Maric Nadja P

Abstract excerpt

Hypothalamic-pituitary-adrenal (HPA) axis activity mediates the relationship between childhood trauma (CT) and psychosis. The FKBP5 gene, one of the key regulators of HPA axis activity after stress exposure, has been found associated with psychosis. Allele-specific and CT related FKBP5 demethylation in intron 7 was revealed in different psychiatric disorders. However, no studies have investigated FKBP5...

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PMID: 33933892
DOI: 10.1016/j.psyneuen.2021.105205

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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