Article
Allele-specific FKBP5 DNA demethylation mediates gene-childhood trauma interactions.
Nature neuroscience - 1 Jan 2013
Klengel Torsten, Mehta Divya, Anacker Christoph, Rex-Haffner Monika, Pruessner Jens C, Pariante Carmine M, Pace Thaddeus W W, Mercer Kristina B, Mayberg Helen S, Bradley Bekh, Nemeroff Charles B, Holsboer Florian, Heim Christine M, Ressler Kerry J, Rein Theo, Binder Elisabeth B
Abstract excerpt
Although the fact that genetic predisposition and environmental exposures interact to shape development and function of the human brain and, ultimately, the risk of psychiatric disorders has drawn wide interest, the corresponding molecular mechanisms have not yet been elucidated. We found that a functional polymorphism altering chromatin interaction between the transcription start site and long-range enhancers in...
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