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Article

Genetic variation in FKBP5 associated with the extent of stress hormone dysregulation in major depression.

Genes, brain, and behavior - 1 Apr 2013

Menke A, Klengel T, Rubel J, Brückl T, Pfister H, Lucae S, Uhr M, Holsboer F, Binder E B

Abstract excerpt

The FK506 binding protein 51 or FKBP5 has been implicated in the regulation of glucocorticoid receptor (GR) sensitivity, and genetic variants in this gene have been associated with mood and anxiety disorders. GR resistance and associated stress hormone dysregulation are among the most robust biological findings in major depression, the extent of which may be moderated by FKBP5 polymorphisms. FKBP5 mRNA expression...

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Source

Identifiers

PMID: 23406438
DOI: 10.1111/gbb.12026

Genes

FKBP5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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