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Article

Interaction of FKBP5 gene variants and adverse life events in predicting depression onset: results from a 10-year prospective community study.

The American journal of psychiatry - 1 Oct 2011

Zimmermann Petra, Brückl Tanja, Nocon Agnes, Pfister Hildegard, Binder Elisabeth B, Uhr Manfred, Lieb Roselind, Moffitt Terrie E, Caspi Avshalom, Holsboer Florian, Ising Marcus

Abstract excerpt

OBJECTIVE: The binding protein FKBP5 is an important modulator of the function of the glucocorticoid receptor, the main receptor of the stress hormone system. This turns the FKBP5 gene into a key candidate for gene-environment interactions, which are considered critical for pathogenesis of stress-related disorders. The authors explored gene-environment interactions between FKBP5 gene variants and adverse life...

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Identifiers

PMID: 21865530
DOI: 10.1176/appi.ajp.2011.10111577
PMCID: PMC3856576

Genes

FKBP5

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