The influence of FKBP5 genotype on expression of FKBP5 and other glucocorticoid-regulated genes, dependent on trauma exposure.

doi:10.1111/gbb.12342

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Article

The influence of FKBP5 genotype on expression of FKBP5 and other glucocorticoid-regulated genes, dependent on trauma exposure.

Genes, brain, and behavior - 1 Feb 2017

Yeo S, Enoch M-A, Gorodetsky E, Akhtar L, Schuebel K, Roy A, Goldman D

Abstract excerpt

The FK506 binding protein 51 (FKBP5), an intrinsic regulator of the glucocorticoid receptor, has been associated with pathological behaviors particularly in the context of childhood trauma (CT), via a putatively regulatory polymorphism, rs1360780. However, trans- and cis-acting effects of this locus and its interaction with CT are incompletely understood. To study its effects on the expression of...

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PMID: 27648526
DOI: 10.1111/gbb.12342
PMCID: PMC6233292

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FKBP5

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