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Article

Independent recruitment of Igh alleles in V(D)J recombination.

Nature communications - 17 Dec 2014

Alves-Pereira Clara F, de Freitas Raquel, Lopes Telma, Gardner Rui, Marta Filipa, Vieira Paulo, Barreto Vasco M

Abstract excerpt

How the vast majority of B cells express only one of the two alleles at their immunoglobulin loci remains a biological puzzle. Here, in mice reconstituted with a single haematopoietic stem cell, we demonstrate that each of the two immunoglobulin heavy chain (Igh) alleles has a similar probability to be the first to undergo V(H) to DJ(H) rearrangement. We also observe this similar probability in clones from...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Immunoglobulin Heavy Chains

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Source

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Identifiers

PMID: 25517887
DOI: 10.1038/ncomms6623
PMCID: PMC4351640

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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