Allelic exclusion of immunoglobulin gene rearrangement and expression: why and how?

doi:10.1016/s1044-5323(02)00044-1

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Article

Allelic exclusion of immunoglobulin gene rearrangement and expression: why and how?

Seminars in immunology - 1 Jun 2002

Schlissel Mark

Abstract excerpt

Since the discovery of the allelic exclusion of immunoglobulin (Ig) gene expression by Pervis in the 1960s [J. Exp. Med. 122 (1965) 853], much attention has been focused on its mechanism. Much less attention has been paid, however, to the question of why B cells demonstrate such unusual genetic regulation of antigen receptor gene expression. A large body of literature implicates the Ig gene products as feedback...

Topics

Alleles
Animals
DNA Nucleotidyltransferases
Feedback
Gene Expression
Gene Rearrangement, B-Lymphocyte
Genes, Immunoglobulin
Humans
Models, Immunological
Recombinases

Source

Open in PubMed

Identifiers

PMID: 12160648
DOI: 10.1016/s1044-5323(02)00044-1

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