Mice triallelic for the Ig heavy chain locus: implications for VHDJH recombination.

doi:10.4049/jimmunol.166.9.5638

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Article

Mice triallelic for the Ig heavy chain locus: implications for VHDJH recombination.

Journal of immunology (Baltimore, Md. : 1950) - 1 May 2001

Barreto V, Meo T, Cumano A

Abstract excerpt

V(H)DJ(H) recombination has been extensively studied in mice carrying an Ig heavy chain rearranged transgene. In most models, inhibition of endogenous Ig rearrangement occurs, consistently with the feedback model of IgH recombination. Nonetheless, an incomplete IgH allelic exclusion is a recurrent observation in these animals. Furthermore, transgene expression in ontogeny is likely to start before somatic...

Topics

Alleles
Animals
Antibody Diversity
Antibody Specificity
B-Lymphocytes
Base Sequence
Chimera
Crosses, Genetic
Female
Gene Rearrangement, B-Lymphocyte, Heavy Chain
Genetic Markers

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Immunoglobulin Allotypes

Immunoglobulin Heavy Chains

Immunoglobulin J-Chains

Immunoglobulin Variable Region

Male

Mice

Mice, Inbred A

Source

Open in PubMed

Identifiers

PMID: 11313404
DOI: 10.4049/jimmunol.166.9.5638

Genes

RAG2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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