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Article

Mice triallelic for the Ig heavy chain locus: implications for VHDJH recombination.

Journal of immunology (Baltimore, Md. : 1950) - 1 May 2001

Barreto V, Meo T, Cumano A

Abstract excerpt

V(H)DJ(H) recombination has been extensively studied in mice carrying an Ig heavy chain rearranged transgene. In most models, inhibition of endogenous Ig rearrangement occurs, consistently with the feedback model of IgH recombination. Nonetheless, an incomplete IgH allelic exclusion is a recurrent observation in these animals. Furthermore, transgene expression in ontogeny is likely to start before somatic...

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Source

Identifiers

PMID: 11313404
DOI: 10.4049/jimmunol.166.9.5638

Genes

RAG2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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