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Article

Long-Range Control of V(D)J Recombination & Allelic Exclusion: Modeling Views.

Advances in immunology - 1 Jan 2015

Outters Pernelle, Jaeger Sébastien, Zaarour Nancy, Ferrier Pierre

Abstract excerpt

Allelic exclusion of immunoglobulin (Ig) and T-cell receptor (TCR) genes ensures the development of B and T lymphocytes operating under the mode of clonal selection. This phenomenon associates asynchronous V(D)J recombination events at Ig or TCR alleles and inhibitory feedback control. Despite years of intense research, however, the mechanisms that sustain asymmetric choice in random Ig/TCR dual allele usage and...

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Identifiers

PMID: 26477371
DOI: 10.1016/bs.ai.2015.08.002

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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