Article
Rearrangement/hypermutation/gene conversion: when, where and why?
Immunology today - 1 Feb 1996
Weill J C, Reynaud C A
Abstract excerpt
Diversification strategies for immunoglobulins vary widely in different species. Here, Jean-Claude Weill and Claude-Agnès Reynaud argue that V(D)J recombination arose as a means for achieving allelic exclusion rather than diversity, and postulate that the choice of a diversification strategy is selected along with a specific site of B-cell differentiation. They propose that somatic mutation and gene conversion...
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