Rearrangement/hypermutation/gene conversion: when, where and why?

doi:10.1016/0167-5699(96)80586-x

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Article

Rearrangement/hypermutation/gene conversion: when, where and why?

Immunology today - 1 Feb 1996

Weill J C, Reynaud C A

Abstract excerpt

Diversification strategies for immunoglobulins vary widely in different species. Here, Jean-Claude Weill and Claude-Agnès Reynaud argue that V(D)J recombination arose as a means for achieving allelic exclusion rather than diversity, and postulate that the choice of a diversification strategy is s...

Topics

Animals
B-Lymphocytes
Gene Rearrangement, B-Lymphocyte
Genes, Immunoglobulin
Humans
Immunoglobulin Variable Region
Mutation

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