Article
A zebrafish model of myelodysplastic syndrome produced through tet2 genomic editing.
Molecular and cellular biology - 1 Mar 2015
Gjini Evisa, Mansour Marc R, Sander Jeffry D, Moritz Nadine, Nguyen Ashley T, Kesarsing Michiel, Gans Emma, He Shuning, Chen Si, Ko Myunggon, Kuang You-Yi, Yang Song, Zhou Yi, Rodig Scott, Zon Leonard I, Joung J Keith, Rao Anjana, Look A Thomas
Abstract excerpt
The ten-eleven translocation 2 gene (TET2) encodes a member of the TET family of DNA methylcytosine oxidases that converts 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC) to initiate the demethylation of DNA within genomic CpG islands. Somatic loss-of-function mutations of TET2 are frequently observed in human myelodysplastic syndrome (MDS), which is a clonal malignancy characterized by dysplastic...
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