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Article

Concurrent Zrsr2 mutation and Tet2 loss promote myelodysplastic neoplasm in mice.

Leukemia - 1 Oct 2022

Garcia-Ruiz Cristian, Martínez-Valiente Cristina, Cordón Lourdes, Liquori Alessandro, Fernández-González Raúl, Pericuesta Eva, Sandoval Juan, Cervera José, Gutiérrez-Adán Alfonso, Sanjuan-Pla Alejandra

Abstract excerpt

RNA splicing and epigenetic gene mutations are the most frequent genetic lesions found in patients with myelodysplastic neoplasm (MDS). About 25% of patients present concomitant mutations in such pathways, suggesting a cooperative role in MDS pathogenesis. Importantly, mutations in the splicing factor ZRSR2 frequently associate with alterations in the epigenetic regulator TET2. However, the impact of these...

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Identifiers

PMID: 36030305
DOI: 10.1038/s41375-022-01674-2
PMCID: PMC9522584

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