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Article

Ten-eleven-translocation 2 (TET2) is downregulated in myelodysplastic syndromes.

European journal of haematology - 1 May 2015

Scopim-Ribeiro Renata, Machado-Neto João Agostinho, Campos Paula de Melo, Silva Cleide Aparecida Moreira, Favaro Patricia, Lorand-Metze Irene, Costa Fernando Ferreira, Saad Sara Teresinha Olalla, Traina Fabiola

Abstract excerpt

TET2, a member of the ten-eleven-translocation (TET) family genes that modify DNA by converting 5-methylcytosine (5-mC) to 5-hydroxymethylcytosine (5-hmC), is located in chromosome 4q24 and is frequently mutated in myeloid malignancies. The impact of TET2 mutation on survival outcomes is still controversial; however, functional studies have proved that it is a loss-of-function mutation that impairs myeloid cell...

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Identifiers

PMID: 25200248
DOI: 10.1111/ejh.12445

Genes

TET2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Ten-eleven-translocation 2 (TET2) is downregulated in myelodysplastic syndromes.PMID 25200248Read ↗

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