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Article

TET2 mutations in myelodysplasia and myeloid malignancies.

Nature genetics - 1 Jul 2009

Mullighan Charles G

Abstract excerpt

The genetic basis of myelodysplasia has long been enigmatic, with few common targets of mutation known. A new study reports common mutations in the TET2 gene in myelodysplasia and related myeloid malignancies, suggesting that TET2 has an important role in hematopoiesis and in the pathogenesis of this disease.

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Source

Identifiers

PMID: 19557078
DOI: 10.1038/ng0709-766

Genes

TET2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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TET2 mutations in myelodysplasia and myeloid malignancies.PMID 19557078Read ↗

Mutation in TET2 in myeloid cancers.Semantic proximity Read ↗

Acquired mutations in TET2 are common in myelodysplastic syndromes.Semantic proximity Read ↗

TET2 mutational status affects myelodysplastic syndrome evolution to chronic myelomonocytic leukemiaSemantic proximity Read ↗

Significance of JAK2 and TET2 mutations in myelodysplastic syndromes.Semantic proximity Read ↗

[Molecular and clinical characteristics and prognosis of myelodysplastic neoplasms with biallelic TET2 inactivation].Semantic proximity Read ↗

Genetic characterization of TET1, TET2, and TET3 alterations in myeloid malignancies.Semantic proximity Read ↗

Next-generation sequencing of the TET2 gene in 355 MDS and CMML patients reveals low-abundance mutant clones with early origins, but indicates no definite prognostic value.Semantic proximity Read ↗

Landscape of TET2 Mutations: From Hematological Malignancies to Solid TumorsSemantic proximity Read ↗

Ten-eleven-translocation 2 (TET2) is downregulated in myelodysplastic syndromes.Semantic proximity Read ↗

TET2 mutation in acute myeloid leukemia: biology, clinical significance, and therapeutic insights.Semantic proximity Read ↗

Research Advances in the Mutation of TET2 Gene in Myeloid Maligancies.Semantic proximity Read ↗

Mutational analysis of therapy-related myelodysplastic syndromes and acute myelogenous leukemia.Semantic proximity Read ↗

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