Article
Acquired mutations in TET2 are common in myelodysplastic syndromes.
Nature genetics - 1 Jul 2009
Langemeijer Saskia M C, Kuiper Roland P, Berends Marieke, Knops Ruth, Aslanyan Mariam G, Massop Marion, Stevens-Linders Ellen, van Hoogen Patricia, van Kessel Ad Geurts, Raymakers Reinier A P, Kamping Eveline J, Verhoef Gregor E, Verburgh Estelle, Hagemeijer Anne, Vandenberghe Peter, de Witte Theo, van der Reijden Bert A, Jansen Joop H
Abstract excerpt
Myelodysplastic syndromes (MDS) represent a heterogeneous group of neoplastic hematopoietic disorders. Several recurrent chromosomal aberrations have been associated with MDS, but the genes affected have remained largely unknown. To identify relevant genetic lesions involved in the pathogenesis of MDS, we conducted SNP array-based genomic profiling and genomic sequencing in 102 individuals with MDS and identified...
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