Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Rho-kinase signaling controls nucleocytoplasmic shuttling of class IIa histone deacetylase (HDAC7) and transcriptional activation of orphan nuclear receptor NR4A1.

Biochemical and biophysical research communications - 3 Apr 2015

Compagnucci Claudia, Barresi Sabina, Petrini Stefania, Bertini Enrico, Zanni Ginevra

Abstract excerpt

Rho-kinase (ROCK) has been well documented to play a key role in RhoA-induced actin remodeling. ROCK activation results in myosin light chain (MLC) phosphorylation either by direct action on MLC kinase (MLCK) or by inhibition of MLC phosphatase (MLCP), modulating actin-myosin contraction. We foun...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Active Transport, Cell Nucleus
Share to Cytoskeletal Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Down-Regulation

Share to GTPase-Activating Proteins

Share to Histone Deacetylases

Share to Induced Pluripotent Stem Cells

Share to rho-Associated Kinases

Share to Transcriptional Activation

Source

Identifiers

PMID: 25511694
DOI: 10.1016/j.bbrc.2014.12.033

Genes

HDAC7
OPHN1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25511694-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Rho-kinase signaling controls nucleocytoplasmic shuttling of class IIa histone deacetylase (HDAC7) and transcriptional activation of orphan nuclear receptor NR4A1.PMID 25511694Read ↗

Rho Kinase Inhibition Is Essential During In Vitro Neurogenesis and Promotes Phenotypic Rescue of Human Induced Pluripotent Stem Cell-Derived Neurons With Oligophrenin-1 Loss of Function.Semantic proximity Read ↗

Rho Kinases in Embryonic Development and Stem Cell ResearchSemantic proximity Read ↗

Rocking the Boat: The Decisive Roles of Rho Kinases During Oocyte, Blastocyst, and Stem Cell DevelopmentSemantic proximity Read ↗

Targeting ROCK signaling in health, malignant and non-malignant diseases.Semantic proximity Read ↗

Role of RHO family interacting cell polarization regulators (RIPORs) in health and disease: Recent advances and prospectsSemantic proximity Read ↗

Calcium signals act through histone deacetylase to mediate pronephric kidney morphogenesisSemantic proximity Read ↗

Rho Kinases in Health and Disease: From Basic Science to Translational Research.Semantic proximity Read ↗

Nuclear Actin Polymerization Regulates Cell Epithelial‐Mesenchymal TransitionSemantic proximity Read ↗

HDAC6 promotes self-renewal and migration/invasion of rhabdomyosarcomaSemantic proximity Read ↗

WNT signaling promotes Nkx2.5 expression and early cardiomyogenesis via downregulation of Hdac1.Semantic proximity Read ↗

What Is the Role of the Rho-ROCK Pathway in Neurologic Disorders?Semantic proximity Read ↗

FERM domain containing protein 7 interacts with the Rho GDP dissociation inhibitor and specifically activates Rac1 signaling.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.