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Article

Calcium signals act through histone deacetylase to mediate pronephric kidney morphogenesis

9 Apr 2018

Abstract excerpt

Background: Autosomal dominant polycystic kidney disease is the most common monogenetic kidney disorder and is linked to mutations in PKD1 and PKD2. PKD2, a Ca2+‐conducting TRP channel enriched in ciliated cells and gated by extracellular signals, is necessary to activate the multifunctional Ca2+/calmodulin–dependent protein kinase type 2 (CaMK‐II), enabling kidney morphogenesis and cilia stability. Results: In...

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PMID: 29633426
DOI: 10.1002/dvdy.24632

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