HDAC6 promotes self-renewal and migration/invasion of rhabdomyosarcoma

Abstract excerpt

<h4>ABSTRACT</h4> Rhabdomyosarcoma (RMS) is a devastating pediatric sarcoma. The survival outcomes remain poor for patients with relapsed or metastatic disease. Effective targeted therapy is lacking due to our limited knowledge of the underlying cellular and molecular mechanisms leading to disease progression. In this study, we used functional assays in vitro and in vivo (zebrafish and xenograft mouse models) t...

Topics

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• Antineoplastic Agents
• Chromatin Assembly and Disassembly
• Combined Modality Therapy
• Drug Design
• Histone Deacetylase Inhibitors Research
• Peptidase Inhibition and Analysis
• Protein Degradation and Inhibitors
• Signaling Pathways in Disease

Identifiers and source

Literature Corpus work

346ac518-8f95-543f-b508-37b5a13a5806

DOI

10.1101/823864