Article
Rho Kinase Inhibition Is Essential During In Vitro Neurogenesis and Promotes Phenotypic Rescue of Human Induced Pluripotent Stem Cell-Derived Neurons With Oligophrenin-1 Loss of Function.
Stem cells translational medicine - 1 Jul 2016
Compagnucci Claudia, Barresi Sabina, Petrini Stefania, Billuart Pierre, Piccini Giorgia, Chiurazzi Pietro, Alfieri Paolo, Bertini Enrico, Zanni Ginevra
Abstract excerpt
UNLABELLED: : Rho-GTPases have relevant functions in various aspects of neuronal development, such as differentiation, migration, and synaptogenesis. Loss of function of the oligophrenin-1 gene (OPHN1) causes X-linked intellectual disability with cerebellar hypoplasia and leads to hyperactivation of the rho kinase (ROCK) pathway. ROCK mainly acts through phosphorylation of the myosin phosphatase targeting subunit...
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