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Article

FERM domain containing protein 7 interacts with the Rho GDP dissociation inhibitor and specifically activates Rac1 signaling.

PloS one - 1 Jan 2013

Pu Jiali, Mao Yanfang, Lei Xiaoguang, Yan Yaping, Lu Xiaoxiong, Tian Jun, Yin Xinzhen, Zhao Guohua, Zhang Baorong

Abstract excerpt

The FERM domain containing protein 7 gene (FRMD7) associated with the X-linked disorder idiopathic congenital nystagmus (ICN) is involved in the regulation of neurite elongation during neuronal development. Members of the Rho family of small G-proteins (Rho GTPases) are key regulators of the actin cytoskeleton and are implicated in the control of neuronal morphology. The Rho GDP dissociation inhibitor alpha,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23967341
DOI: 10.1371/journal.pone.0073108
PMCID: PMC3742540

Genes

FRMD7

Variants

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