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Article

Allelic exclusion of TCR α-chains upon severe restriction of Vα repertoire.

PloS one - 1 Jan 2014

Rybakin Vasily, Westernberg Luise, Fu Guo, Kim Hee-Ok, Ampudia Jeanette, Sauer Karsten, Gascoigne Nicholas R J

Abstract excerpt

Development of thymocytes through the positive selection checkpoint requires the rearrangement and expression of a suitable T cell receptor (TCR) α-chain that can pair with the already-expressed β-chain to make a TCR that is selectable. That is, it must have sufficient affinity for self MHC-peptide to induce the signals required for differentiation, but not too strong so as to induce cell death. Because both...

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Source

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Identifiers

PMID: 25500569
DOI: 10.1371/journal.pone.0114320
PMCID: PMC4264757

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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