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Article

GATA3 Abundance Is a Critical Determinant of T Cell Receptor β Allelic Exclusion.

Molecular and cellular biology - 15 Jun 2017

Ku Chia-Jui, Sekiguchi JoAnn M, Panwar Bharat, Guan Yuanfang, Takahashi Satoru, Yoh Keigyou, Maillard Ivan, Hosoya Tomonori, Engel James Douglas

Abstract excerpt

Allelic exclusion describes the essential immunological process by which feedback repression of sequential DNA rearrangements ensures that only one autosome expresses a functional T or B cell receptor. In wild-type mammals, approximately 60% of cells have recombined the DNA of one T cell receptor β (TCRβ) V-to-DJ-joined allele in a functional configuration, while the second allele has recombined only the DJ...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Receptors, Antigen, T-Cell, alpha-beta

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Identifiers

PMID: 28320875
DOI: 10.1128/MCB.00052-17
PMCID: PMC5452726

Genes

GATA3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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