Article
Receptor-specific allelic exclusion of TCRV alpha-chains during development.
Journal of immunology (Baltimore, Md. : 1950) - 15 Aug 1998
Boyd R, Kozieradzki I, Chidgey A, Mittrücker H W, Bouchard D, Timms E, Kishihara K, Ong C J, Chui D, Marth J D, Mak T W, Penninger J M
Abstract excerpt
Expression of a single Ag receptor on lymphocytes is maintained via allelic exclusion that generates cells with a clonal receptor repertoire. We show in normal mice and mice expressing functionally rearranged TCR alphabeta transgenes that allelic exclusion at the TCR alpha locus is not operationa...
Topics
- Alleles
- Animals
- Cell Differentiation
- Cell Membrane
- Dynamins
- GTP Phosphohydrolases
- Gene Rearrangement, alpha-Chain T-Cell Antigen Receptor
- Gene Rearrangement, beta-Chain T-Cell Antigen Receptor
- Leukocyte Common Antigens
- Membrane Proteins
- Mice
- Mice, Knockout
- Mice, Transgenic