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Article

Receptor-specific allelic exclusion of TCRV alpha-chains during development.

Journal of immunology (Baltimore, Md. : 1950) - 15 Aug 1998

Boyd R, Kozieradzki I, Chidgey A, Mittrücker H W, Bouchard D, Timms E, Kishihara K, Ong C J, Chui D, Marth J D, Mak T W, Penninger J M

Abstract excerpt

Expression of a single Ag receptor on lymphocytes is maintained via allelic exclusion that generates cells with a clonal receptor repertoire. We show in normal mice and mice expressing functionally rearranged TCR alphabeta transgenes that allelic exclusion at the TCR alpha locus is not operational in immature thymocytes, whereas most mature T cells express a single TCRV alpha-chain. TCRV alpha allelic exclusion...

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PMID: 9712036

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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