Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

C-MYC transcriptionally amplifies SOX2 target genes to regulate self-renewal in multipotent otic progenitor cells.

Stem cell reports - 13 Jan 2015

Kwan Kelvin Y, Shen Jun, Corey David P

Abstract excerpt

Sensorineural hearing loss is caused by the loss of sensory hair cells and neurons of the inner ear. Once lost, these cell types are not replaced. Two genes expressed in the developing inner ear are c-Myc and Sox2. We created immortalized multipotent otic progenitor (iMOP) cells, a fate-restricted cell type, by transient expression of C-MYC in SOX2-expressing otic progenitor cells. This activated the endogenous...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cellular Microenvironment
Share to Fibroblast Growth Factor 2

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hair Cells, Auditory

Share to Karyotype

Share to Multipotent Stem Cells

Share to Proto-Oncogene Proteins c-myc

Share to SOXB1 Transcription Factors

Share to Transduction, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 25497456
DOI: 10.1016/j.stemcr.2014.11.001
PMCID: PMC4297878

Genes

MYC
SOX2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

C-MYC transcriptionally amplifies SOX2 target genes to regulate self-renewal in multipotent otic progenitor cells.PMID 25497456Read ↗

Open chromatin dynamics in prosensory cells of the embryonic mouse cochlea.Semantic proximity Read ↗

Capturing self-renewing multipotent neural crest stem cells from human pluripotent stem cellsSemantic proximity Read ↗

MYC gene delivery to adult mouse utricles stimulates proliferation of postmitotic supporting cells in vitro.Semantic proximity Read ↗

Molecular characterization of conditionally immortalized cell lines derived from mouse early embryonic inner ear.Semantic proximity Read ↗

Single-cell transcriptomic atlas reveals increased regeneration in diseased human inner earsSemantic proximity Read ↗

Correct timing of proliferation and differentiation is necessary for normal inner ear development and auditory hair cell viability.Semantic proximity Read ↗

OCT4 maintains self-renewal and reverses senescence in human hair follicle mesenchymal stem cells through the downregulation of p21 by DNA methyltransferasesSemantic proximity Read ↗

Loss of Zbtb20 disrupts cochlear supporting cell differentiation and maturation and extends the postnatal hair cell regenerative window in mice.Semantic proximity Read ↗

Development of the Mouse and Human Cochlea at Single Cell ResolutionSemantic proximity Read ↗

Canonical Notch signaling plays an instructive role in auditory supporting cell development.Semantic proximity Read ↗

Single-cell atlas comparison across vertebrates reveals evolution of auditory cell types and mechanisms for hair cell regenerationSemantic proximity Read ↗

Sox2(+) stem/progenitor cells in the adult mouse pituitary support organ homeostasis and have tumor-inducing potential.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.