Article

Single-cell atlas comparison across vertebrates reveals evolution of auditory cell types and mechanisms for hair cell regeneration

2024-06-28

Abstract excerpt

<title>Abstract</title> The loss of auditory hair cell in mammals including humans results in permanent hearing impairment, as they lack the inherent capacity for regeneration. In contrast, the lower vertebrates exhibit remarkable capacity for hair cell regeneration and hearing restoration, however, the mechanisms remain unclear. In this work, we characterized the first single-cell atlas of inner ear from the...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a44f8626-c998-5722-a60c-a76472946d73
DOI: 10.21203/rs.3.rs-4508608/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Single-cell atlas comparison across vertebrates reveals evolution of auditory cell types and mechanisms for hair cell regenerationDOI 10.21203/rs.3.rs-4508608/v1Read

Single-cell transcriptomic atlas reveals increased regeneration in diseased human inner earsSemantic proximity Read

Single-Cell Transcriptomic Profiling of the Zebrafish Inner Ear Reveals Molecularly Distinct Hair Cell and Supporting Cell SubtypesSemantic proximity Read

Single-cell RNA-sequencing of zebrafish hair cells reveals the novel genes potentially involved in hearing lossSemantic proximity Read

Mechanosensory neuron regeneration in adult DrosophilaSemantic proximity Read

Development of the Mouse and Human Cochlea at Single Cell ResolutionSemantic proximity Read

Inner ear supporting cells: rethinking the silent majority.Semantic proximity Read

The Notch ligand Jagged1 plays a dual role in cochlear hair cell regenerationSemantic proximity Read

Characterization of the transcriptome of nascent hair cells and identification of direct targets of the Atoh1 transcription factor.Semantic proximity Read

Single-cell sequencing reveals the new existence form of dermal papilla cells in the hair follicle regeneration of cashmere goatsSemantic proximity Read

Zebrafish as a Biomedical Model for Stem Cells Research in Hearing Impairment Semantic proximity Read

A Single-Cell Level Comparison of Human Inner Ear Organoids and the Human Cochlea and Vestibular OrgansSemantic proximity Read

Characterizing Adult cochlear supporting cell transcriptional diversity using single-cell RNA-Seq: Validation in the adult mouse and translational implications for the adult human cochleaSemantic proximity Read