Article

Loss of Zbtb20 disrupts cochlear supporting cell differentiation and maturation and extends the postnatal hair cell regenerative window in mice.

2026-08-20

Abstract excerpt

Cochlear hair cell (HC) loss is a leading cause of hearing loss in humans. HCs can be generated from adjacent supporting cells (SCs); however, this regenerative capacity is lost after the onset of hearing. Using Emx2Cre Zbtb20 knockout mice, we show that ZBTB20 deficiency delays cell-cycle exit, differentiation, and maturation of cochlear SCs. Transcriptomic analysis of postnatal cochlear sensory epithelia indicat...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a9f59b3a-ece2-579d-9af4-9c831842681e
DOI: 10.64898/2026.08.19.745776

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Loss of Zbtb20 disrupts cochlear supporting cell differentiation and maturation and extends the postnatal hair cell regenerative window in mice.DOI 10.64898/2026.08.19.745776Read

Reactivation of the progenitor gene Trim71 enhances the mitotic and hair cell-forming potential of cochlear supporting cellsSemantic proximity Read

Single-cell transcriptomic atlas reveals increased regeneration in diseased human inner earsSemantic proximity Read

The Notch ligand Jagged1 plays a dual role in cochlear hair cell regenerationSemantic proximity Read

Single-cell atlas comparison across vertebrates reveals evolution of auditory cell types and mechanisms for hair cell regenerationSemantic proximity Read

Development and Regeneration of the Inner EarSemantic proximity Read

Canonical Notch signaling plays an instructive role in auditory supporting cell development.Semantic proximity Read

MEKK4 Signaling Regulates Sensory Cell Development and Function in the Mouse Inner Ear.Semantic proximity Read

The Dual Roles of Triiodothyronine in Regulating the Morphology of Hair Cells and Supporting Cells during Critical Periods of Mouse Cochlear DevelopmentSemantic proximity Read

Development of the Mouse and Human Cochlea at Single Cell ResolutionSemantic proximity Read

C-MYC transcriptionally amplifies SOX2 target genes to regulate self-renewal in multipotent otic progenitor cells.Semantic proximity Read

Characterizing Adult cochlear supporting cell transcriptional diversity using single-cell RNA-Seq: Validation in the adult mouse and translational implications for the adult human cochleaSemantic proximity Read

Unraveling the roles of <i>Mast4</i> in amelogenesis via regulating DLX3 and stem cell maintenance of mouse incisorsSemantic proximity Read