Article
Sox2(+) stem/progenitor cells in the adult mouse pituitary support organ homeostasis and have tumor-inducing potential.
Cell stem cell - 3 Oct 2013
Andoniadou Cynthia Lilian, Matsushima Danielle, Mousavy Gharavy Seyedeh Neda, Signore Massimo, Mackintosh Albert Ian, Schaeffer Marie, Gaston-Massuet Carles, Mollard Patrice, Jacques Thomas Stanley, Le Tissier Paul, Dattani Mehul Tulsidas, Pevny Larysa Halyna, Martinez-Barbera Juan Pedro
Abstract excerpt
Sox2(+) adult mouse pituitary cells can self-renew and terminally differentiate in vitro, but their physiological role in vivo and possible contribution to oncogenesis remain largely unknown. Using genetic lineage tracing, we show here that the Sox2(+) cell compartment of both the embryonic and adult pituitary contains stem/progenitor cells that are able to differentiate into all hormone-producing lineages and...
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