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Article

MYC gene delivery to adult mouse utricles stimulates proliferation of postmitotic supporting cells in vitro.

PloS one - 1 Jan 2012

Burns Joseph C, Yoo James J, Atala Anthony, Jackson John D

Abstract excerpt

The inner ears of adult humans and other mammals possess a limited capacity for regenerating sensory hair cells, which can lead to permanent auditory and vestibular deficits. During development and regeneration, undifferentiated supporting cells within inner ear sensory epithelia can self-renew and give rise to new hair cells; however, these otic progenitors become depleted postnatally. Therefore, reprogramming...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23119091
DOI: 10.1371/journal.pone.0048704
PMCID: PMC3484123

Genes

MYC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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