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Article

Hand, an evolutionarily conserved bHLH transcription factor required for Drosophila cardiogenesis and hematopoiesis.

Development (Cambridge, England) - 1 Mar 2006

Han Zhe, Yi Peng, Li Xiumin, Olson Eric N

Abstract excerpt

The Hand gene family encodes highly conserved basic helix-loop-helix (bHLH) transcription factors that play crucial roles in cardiac and vascular development in vertebrates. In Drosophila, a single Hand gene is expressed in the three major cell types that comprise the circulatory system: cardioblasts, pericardial nephrocytes and lymph gland hematopoietic progenitors, but its function has not been determined. Here...

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Identifiers

PMID: 16467358
DOI: 10.1242/dev.02285

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Hand, an evolutionarily conserved bHLH transcription factor required for Drosophila cardiogenesis and hematopoiesis.PMID 16467358Read ↗

The bHLH Transcription Factor Hand Regulates the Expression of Genes Critical to Heart and Muscle Function in Drosophila melanogaster.Semantic proximity Read ↗

The Drosophila Hand gene is required for remodeling of the developing adult heart and midgut during metamorphosis.Semantic proximity Read ↗

Analysis of the Hand1 cell lineage reveals novel contributions to cardiovascular, neural crest, extra-embryonic, and lateral mesoderm derivatives.Semantic proximity Read ↗

The Hand1 and Hand2 transcription factors regulate expansion of the embryonic cardiac ventricles in a gene dosage-dependent manner.Semantic proximity Read ↗

Requirement of the LIM homeodomain transcription factor tailup for normal heart and hematopoietic organ formation in Drosophila melanogaster.Semantic proximity Read ↗

Hand2 Is an Essential Regulator for Two Notch-Dependent Functions within the Embryonic EndocardiumSemantic proximity Read ↗

A loss-of-function mutation in the binding domain of HAND1 predicts hypoplasia of the human heartsSemantic proximity Read ↗

HAND proteins: molecular mediators of cardiac development and congenital heart disease.Semantic proximity Read ↗

A bHLH code for cardiac morphogenesis.Semantic proximity Read ↗

Hand2 function in second heart field progenitors is essential for cardiogenesis.Semantic proximity Read ↗

In-Silico analysis of HAND subclass bHLH transcription factor in CardiogenesisSemantic proximity Read ↗

PDGFRA is a conserved HAND2 effector during early cardiac development.Semantic proximity Read ↗

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