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Article

HAND transcription factors cooperatively specify the aorta and pulmonary trunk.

Developmental biology - 1 Aug 2021

Vincentz Joshua W, Firulli Beth A, Toolan Kevin P, Osterwalder Marco, Pennacchio Len A, Firulli Anthony B

Abstract excerpt

Congenital heart defects (CHDs) affecting the cardiac outflow tract (OFT) constitute a significant cause of morbidity and mortality. The OFT develops from migratory cell populations which include the cardiac neural crest cells (cNCCs) and secondary heart field (SHF) derived myocardium and endocardium. The related transcription factors HAND1 and HAND2 have been implicated in human CHDs involving the OFT. Although...

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Source

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Identifiers

PMID: 33757801
DOI: 10.1016/j.ydbio.2021.03.011
PMCID: PMC8172455

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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