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Article

Coronary arterial development is regulated by a Dll4-Jag1-EphrinB2 signaling cascade.

eLife - 4 Dec 2019

Travisano Stanislao Igor, Oliveira Vera Lucia, Prados Belén, Grego-Bessa Joaquim, Piñeiro-Sabarís Rebeca, Bou Vanesa, Gómez Manuel J, Sánchez-Cabo Fátima, MacGrogan Donal, de la Pompa José Luis

Abstract excerpt

Coronaries are essential for myocardial growth and heart function. Notch is crucial for mouse embryonic angiogenesis, but its role in coronary development remains uncertain. We show Jag1, Dll4 and activated Notch1 receptor expression in sinus venosus (SV) endocardium. Endocardial Jag1 removal blocks SV capillary sprouting, while Dll4 inactivation stimulates excessive capillary growth, suggesting that ligand...

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Share to Coronary Vessels
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Heart Ventricles

Share to Human Umbilical Vein Endothelial Cells

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Share to Neovascularization, Physiologic

Share to NFATC Transcription Factors

Share to Vascular Remodeling

Source

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Identifiers

PMID: 31789590
DOI: 10.7554/eLife.49977
PMCID: PMC6917494

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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