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Article

Genome-wide bisulfite sequencing in zygotes identifies demethylation targets and maps the contribution of TET3 oxidation.

Cell reports - 24 Dec 2014

Peat Julian R, Dean Wendy, Clark Stephen J, Krueger Felix, Smallwood Sébastien A, Ficz Gabriella, Kim Jong Kyoung, Marioni John C, Hore Timothy A, Reik Wolf

Abstract excerpt

Fertilization triggers global erasure of paternal 5-methylcytosine as part of epigenetic reprogramming during the transition from gametic specialization to totipotency. This involves oxidation by TET3, but our understanding of its targets and the wider context of demethylation is limited to a small fraction of the genome. We employed an optimized bisulfite strategy to generate genome-wide methylation profiles of...

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Identifiers

PMID: 25497087
DOI: 10.1016/j.celrep.2014.11.034
PMCID: PMC4542306

Genes

TET3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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