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Article

TET proteins safeguard bivalent promoters from de novo methylation in human embryonic stem cells.

Nature genetics - 1 Jan 2018

Verma Nipun, Pan Heng, Doré Louis C, Shukla Abhijit, Li Qing V, Pelham-Webb Bobbie, Teijeiro Virginia, González Federico, Krivtsov Andrei, Chang Chan-Jung, Papapetrou Eirini P, He Chuan, Elemento Olivier, Huangfu Danwei

Abstract excerpt

TET enzymes oxidize 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC), which can lead to DNA demethylation. However, direct connections between TET-mediated DNA demethylation and transcriptional output are difficult to establish owing to challenges in distinguishing global versus locus-specific effects. Here we show that TET1, TET2 and TET3 triple-knockout (TKO) human embryonic stem cells (hESCs) exhibit...

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Source

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Identifiers

PMID: 29203910
DOI: 10.1038/s41588-017-0002-y
PMCID: PMC5742051

Genes

PAX6
TET1
TET2
TET3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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