Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Distinct dynamics of parental 5-hydroxymethylcytosine during human preimplantation development regulate early lineage gene expression

30 Jul 2024

Abstract excerpt

The conversion of DNA 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC) by TET enzymes represents a significant epigenetic modification, yet its role in early human embryos remains largely unknown. Here we showed that the early human embryo inherited a significant amount of 5hmCs from an oocyte, which unexpectedly underwent de novo hydroxymethylation during its growth. Furthermore, the generation of 5hmC...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Epigenetics and DNA Methylation
Share to Genetic Syndromes and Imprinting
Share to Prenatal Screening and Diagnostics

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 39080410
DOI: 10.1038/s41556-024-01475-y

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Distinct dynamics of parental 5-hydroxymethylcytosine during human preimplantation development regulate early lineage gene expressionPMID 39080410Read ↗

TET enzyme driven epigenetic reprogramming in early embryos and its implication on long-term healthSemantic proximity Read ↗

Reprogramming of the paternal genome upon fertilization involves genome-wide oxidation of 5-methylcytosineSemantic proximity Read ↗

Epigenetic dynamics during preimplantation developmentSemantic proximity Read ↗

Maternal TET3 is dispensable for embryonic development but is required for neonatal growthSemantic proximity Read ↗

Aberrant DNA and histone methylation during zygotic genome activation in goat cloned embryos.Semantic proximity Read ↗

The role of DNA hydroxymethylation and TET enzymes in placental development and pregnancy outcomeSemantic proximity Read ↗

Epigenetic regulation of early human embryo developmentSemantic proximity Read ↗

Insights into epigenetic patterns in mammalian early embryosSemantic proximity Read ↗

Distinct and overlapping control of 5-methylcytosine and 5-hydroxymethylcytosine by the TET proteins in human cancer cellsSemantic proximity Read ↗

Vitamin C Rescues in vitro Embryonic Development by Correcting Impaired Active DNA DemethylationSemantic proximity Read ↗

Epigenetic Function of TET Family, 5-Methylcytosine, and 5-Hydroxymethylcytosine in Hematologic MalignanciesSemantic proximity Read ↗

The emerging role of TET enzymes in the immune microenvironment at the maternal-fetal interface during decidualization and early pregnancySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.