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Article

The role of Tet3 DNA dioxygenase in epigenetic reprogramming by oocytes.

Nature - 4 Sept 2011

Gu Tian-Peng, Guo Fan, Yang Hui, Wu Hai-Ping, Xu Gui-Fang, Liu Wei, Xie Zhi-Guo, Shi Linyu, He Xinyi, Jin Seung-gi, Iqbal Khursheed, Shi Yujiang Geno, Deng Zixin, Szabó Piroska E, Pfeifer Gerd P, Li Jinsong, Xu Guo-Liang

Abstract excerpt

Sperm and eggs carry distinctive epigenetic modifications that are adjusted by reprogramming after fertilization. The paternal genome in a zygote undergoes active DNA demethylation before the first mitosis. The biological significance and mechanisms of this paternal epigenome remodelling have remained unclear. Here we report that, within mouse zygotes, oxidation of 5-methylcytosine (5mC) occurs on the paternal...

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Identifiers

PMID: 21892189
DOI: 10.1038/nature10443

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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Research trail→

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The role of Tet3 DNA dioxygenase in epigenetic reprogramming by oocytes.PMID 21892189Read ↗

Maternal TET3 is dispensable for embryonic development but is required for neonatal growthSemantic proximity Read ↗

Reprogramming of the paternal genome upon fertilization involves genome-wide oxidation of 5-methylcytosineSemantic proximity Read ↗

Tet1 controls meiosis by regulating meiotic gene expression.Semantic proximity Read ↗

TET enzyme driven epigenetic reprogramming in early embryos and its implication on long-term healthSemantic proximity Read ↗

Distinct dynamics of parental 5-hydroxymethylcytosine during human preimplantation development regulate early lineage gene expressionSemantic proximity Read ↗

Genome-wide bisulfite sequencing in zygotes identifies demethylation targets and maps the contribution of TET3 oxidation.Semantic proximity Read ↗

TET1 Catalytic Activity is Required for Reprogramming of Imprinting Control Regions and Patterning of Sperm-Specific Hypomethylated RegionsSemantic proximity Read ↗

EHMT2 and SETDB1 protect the maternal pronucleus from 5mC oxidationSemantic proximity Read ↗

Transcriptional activation of transposable elements in mouse zygotes is independent of Tet3-mediated 5-methylcytosine oxidationSemantic proximity Read ↗

Vitamin C Rescues in vitro Embryonic Development by Correcting Impaired Active DNA DemethylationSemantic proximity Read ↗

Crosstalk between the Methyl-Cytosine Dioxygenase TET3 and the Methyl-CpG-binding protein MECP2 Controls Neuronal MaturationSemantic proximity Read ↗

A role for the elongator complex in zygotic paternal genome demethylation.Semantic proximity Read ↗

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