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Article

Cdc42 induces EGF receptor protein accumulation and promotes EGF receptor nuclear transport and cellular transformation.

FEBS letters - 16 Jan 2015

Wang Xiao-Yu, Gan Ming-Xi, Li Yong, Zhan Wei-Hua, Han Tian-Yu, Han Xiao-Jian, Cheng Jin-Quan, Wang Jian-Bin

Abstract excerpt

Cdc42 is a Ras-related small GTP-binding protein. A previous study has shown that Cdc42 binding to the γ subunit of the coatomer protein complex (γCOP) is essential for Cdc42-regulated cellular transformation, but the molecular mechanism involved is not well understood. Here, we demonstrate that constitutively-active Cdc42 binding to γCOP induced the accumulation of epithelial growth factor receptor (EGFR) in the...

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Identifiers

PMID: 25497016
DOI: 10.1016/j.febslet.2014.11.049

Genes

EGF
EGFR
JUN

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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