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Targeting Rac and Cdc42 GTPases in Cancer

1 Jun 2018

Abstract excerpt

Abstract Rac and Cdc42 are small GTPases that have been linked to multiple human cancers and are implicated in epithelial to mesenchymal transition, cell-cycle progression, migration/invasion, tumor growth, angiogenesis, and oncogenic transformation. With the exception of the P29S driver mutation in melanoma, Rac and Cdc42 are not generally mutated in cancer, but are overexpressed (gene amplification and mRNA...

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PMID: 29858187
DOI: 10.1158/0008-5472.can-18-0619

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