Article
Cdc42 in oncogenic transformation, invasion, and tumorigenesis.
Cellular signalling - 1 Sept 2011
Stengel Kristy, Zheng Yi
Abstract excerpt
The Rho family of GTPases represents a class of Ras-related signaling molecules often deregulated in cancer. Rho GTPases switch from a GDP-bound, inactive state to a GTP-bound, active state in response to extracellular stimuli such as mitogens and extracellular matrix. In addition, Rho GTPase signaling can be altered in response to cell intrinsic factors such as changes in oncogenic or tumor suppressor signaling....
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