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Article

The gamma-subunit of the coatomer complex binds Cdc42 to mediate transformation.

Nature - 15 Jun 2000

Wu W J, Erickson J W, Lin R, Cerione R A

Abstract excerpt

The Ras-related GTP-binding protein Cdc42 is implicated in a variety of biological activities including the establishment of cell polarity in yeast, the regulation of cell morphology, motility and cell-cycle progression in mammalian cells and the induction of malignant transformation. We identified a Cdc42 mutant (Cdc42F28L) which binds GTP in the absence of a guanine nucleotide exchange factor, but still...

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PMID: 10866202
DOI: 10.1038/35015585

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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