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Article

Cdc42 and Ras cooperate to mediate cellular transformation by intersectin-L.

The Journal of biological chemistry - 17 Jun 2005

Wang Jian-Bin, Wu Wen Jin, Cerione Richard A

Abstract excerpt

Cdc42, a Ras-related GTP-binding protein, has been implicated in the regulation of the actin cytoskeleton, membrane trafficking, cell-cycle progression, and malignant transformation. We have shown previously that a Cdc42 mutant (Cdc42(F28L)), capable of spontaneously exchanging GDP for GTP (referred to as "fast-cycling"), transformed NIH 3T3 cells because of its ability to interfere with epidermal growth factor...

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Identifiers

PMID: 15824104
DOI: 10.1074/jbc.M414375200

Genes

EGFR
EGF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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