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Article

Cdc42 GTPase regulates ESCRTs in nuclear envelope sealing and ER remodeling.

The Journal of cell biology - 3 Aug 2020

Lu Michelle Seiko, Drubin David G

Abstract excerpt

Small GTPases of the Rho family are binary molecular switches that regulate a variety of processes including cell migration and oriented cell divisions. Known Cdc42 effectors include proteins involved in cytoskeletal remodeling and kinase-dependent transcription induction, but none are involved in the maintenance of nuclear envelope integrity or ER morphology. Maintenance of nuclear envelope integrity requires...

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Identifiers

PMID: 32556066
DOI: 10.1083/jcb.201910119
PMCID: PMC7401818

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