Article
An activating mutant of Cdc42 that fails to interact with Rho GDP-dissociation inhibitor localizes to the plasma membrane and mediates actin reorganization.
Experimental cell research - 10 Dec 2004
Gibson Richard M, Gandhi Payal N, Tong Xiaofeng, Miyoshi Jun, Takai Yoshimi, Konieczkowski Martha, Sedor John R, Wilson-Delfosse Amy L
Abstract excerpt
Cdc42 is a member of the Rho family of GTPases and plays an important role in the regulation of actin cytoskeletal organization. Activation of Cdc42 and associated signal transduction cascades are dependent upon proper localization of this GTPase. The studies described herein address the hypothesis that Rho GDP-dissociation inhibitor, RhoGDI, plays an essential role in the translocation of Cdc42 to signaling...
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