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Article

A novel Cdc42Hs mutant induces cellular transformation.

Current biology : CB - 1 Oct 1997

Lin R, Bagrodia S, Cerione R, Manor D

Abstract excerpt

Cdc42Hs is a small GTPase of the Rho-subfamily, which regulates signaling pathways that influence cell morphology and polarity, cell-cycle progression and transcription. An essential role for Cdc42Hs in cell growth regulation has been suggested by the finding that the Dbl oncoprotein is an upstream activator-a guanine nucleotide exchange factor (GEF)-for Cdc42Hs, and that activated mutants of the closely related...

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PMID: 9368762
DOI: 10.1016/s0960-9822(06)00338-1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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