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Article

Cdc42 GTPase-activating protein deficiency promotes genomic instability and premature aging-like phenotypes.

Proceedings of the National Academy of Sciences of the United States of America - 23 Jan 2007

Wang Lei, Yang Linda, Debidda Marcella, Witte David, Zheng Yi

Abstract excerpt

Cdc42 is a member of the Rho GTPase family known to regulate cell actin cytoskeleton organization, polarity, and growth, but its function in mammalian organismal physiology remains unclear. We found that natural aging of WT mice is marked with increased Cdc42 activity in various tissues. Among the negative regulators of Cdc42, gene targeting of Cdc42 GTPase-activating protein (Cdc42GAP) results in constitutively...

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Identifiers

PMID: 17227869
DOI: 10.1073/pnas.0609149104
PMCID: PMC1783128

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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